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2016
12-14
Differences in the mutational landscape of triple-negative breast cancer in African Americans and Caucasians Abstract BACKGROUND: Triple-negative breast cancer (TNBC) occurs at higher frequen.... Read More >
2016
12-14
Discovery and genotyping of structural variation from long-read haploid genome sequence data Abstract In an effort to more fully understand the full spectrum of human genetic variation, we generat.... Read More >
2016
12-14
novoBreak: local assembly for breakpoint detection in cancer genomes Abstract We present novoBreak, a genome-wide local assembly algorithm that di.... Read More >
2016
12-14
Mutational landscape of pediatric acute lymphoblastic leukemia. Abstract Current standard of care for patients with pediatric acute lymphoblastic le.... Read More >
2016
09-13
Detection of therapeutically targetable driver and resistance mutations in lung cancer patients by next generation sequencing of cell-free circulating.... Read More >
2016
08-29
High-throughput Phenotyping of Lung Cancer Somatic Mutations. Abstract Recent genome sequencing efforts have identified millions of somatic muta.... Read More >
2016
08-29
Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer Abstract Long noncoding RNAs (lncRNAs) represent an attractive class of candidates to mediate c.... Read More >
2016
08-29
MuSE: accounting for tumor heterogeneity using a sample-specific error model improves sensitivity and specificity in mutation calling from sequencing data Abstract Subclonal mutations reveal imp.... Read More >
2016
05-31
1.《Nature》-PacBio RS II单分子测序解析人类基因组复杂区域 Resolving the complexity of the human genome using single-molecule sequencing The human genome is arguably the most complete mammalian reference assembly1, 2,.... Read More >
2016
05-30
急性淋巴细胞白血病(ALL)是一种起源于淋巴细胞B系或T系细胞的骨髓内异常增生的恶性肿瘤,80%发生在儿童时期(0~9岁),而且年轻患者更易治愈。然而到目前为止,处于15~30岁的青年人群(adolescents and young adults,AYAs)的发病原因还未明确,因此缺乏有效的治疗措施.... Read More >