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2015
12-27
BACKGROUND Prostate cancer is a heterogeneous disease, but current treatments are not based on molecular stratification. We hypothesized that metas.... Read More >
2015
12-24
Recurrent inactivating RASA2 mutations in melanoma Abstract Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent .... Read More >
2015
12-24
Large-scale identification of sequence variants influencing human transcription factor occupancy in vivo Abstract The function of human regulatory regions depends exquisitely on their local geno.... Read More >
2015
12-24
The genomic landscape of juvenile myelomonocytic leukemia Abstract Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm (MPN) of childhood with a poor prognosis. Mutations in.... Read More >
2015
12-24
Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis. Abstract The differentiation of distinct multi.... Read More >
2015
12-23
Comprehensive characterization of complex structural variations in cancer by directly comparing genome sequence reads Abstract The development of hi.... Read More >
2015
12-23
CONSERTING: integrating copy-number analysis with structural-variation detection Abstract We developed Copy Number Segmentation by Regression Tree.... Read More >
2015
12-23
Abstract Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a compre.... Read More >
2015
12-23
LUMPY: a probabilistic framework for structural variant discovery Abstract Comprehensive discovery of structural variation (SV) from whole genom.... Read More >
2015
12-21
前列腺是男人独有的器官,前列腺癌也是长寿男性最容易患的癌症。2012年我国肿瘤登记地区前列腺癌发病率为9.92/10万,列男性恶性肿瘤发病率的第6位。发病年龄在55岁前处于较低水平,55岁后逐渐升高,发病率随着年龄的增长而增长,高峰年龄是70~80岁。全球范围内,前列腺癌更为重要,是男性的第二大好发.... Read More >