分类目录归档:测序世代

2019
09-25
2018
02-25
Mapping the Mouse Cell Atlas by Microwell-Seq Highlights •Development of Microwell-seq, a high-throughput and low-cost scRNA-seq platform •Co.... Read More >
2017
03-23
人参考基因组不同版本区别 CRCH37 vs b37 vs hg19 vs hsd537 vs GRCH38 余欢 如果使用基于GRCH37的衍生参考基因组版本,建议使用hs37d5,这几个版本的基因组的主要区别介绍如下: 1)GRCH37,b37,hs37d5(b37+decoy)与hg19、GRCH38(hg38)的来源: hg19来自UCSC,GRCH37来自NCBI,b37来自千人基.... Read More >
2017
02-28
从事人基因组二代测序三年,从技术的角度看,二代测序的热潮在消退,看不到现有产品的刚性需求,看不到商业模式盈利的可行性。目前只对正常人群利用ctDNA的肿瘤早筛依然充满希望和兴趣。难度很大,临床实验的设计只能考虑前瞻性研究,周期长,费用庞大,illumina的子公司Grail才最有底气,持续看进展。 .... Read More >
2016
12-23
基于癌症基因组的Atlas (TCGA)计划的数据,美国的科学家联合小组已经完成乳腺癌的第一次大规模“蛋白基因组(proteogenomic)”研究,将DNA突变联系到蛋白信号并帮助确定癌症驱动基因。这项研究由美国国家癌症研究所的肿瘤临床蛋白质组学分析联盟成员进行,包括贝勒医学院、MIT和哈佛的Broad研究所,Fred Hutchinson癌症研究所,纽约大学Langone医学中心和华盛顿大学医.... Read More >
2016
12-23
  也许很多人并不了解Richard E. Lenski,但是曾有一张有趣的照片在网走红:打坐的年轻学者背后是如山的细菌培养皿。这位年轻学者是Lenski当时的博士后,他用了那么多培养皿来研究细菌是如何进化出用柠檬酸盐供能的新技能。 Lenski从1988年就开.... Read More >
2016
12-14
Next-generation genotype imputation service and methods Abstract Genotype imputation is a key component of genetic association studies, where it increases power, facilitates meta-analysis, and aid.... Read More >
2016
12-14
Whole-genome analysis of the methylome and hydroxymethylome in normal and malignant lung and liver Abstract DNA methylation at the 5-position of cytosine (5mC) is an epigenetic modification that reg.... Read More >
2016
03-20
Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma Abstract Basal cell carcinoma (BCC) of the skin is the most common malignant neoplasm in humans. BCC i.... Read More >
2016
01-21
Germline Mutations in Predisposition Genes in Pediatric Cancer. Abstract Background The prevalence and spectrum of predisposing mutations among children and adolescents with cancer are largely unk.... Read More >